Propolis (bee glue) Propolis or bee glue is a resinous mixture that honey bees produce by mixing saliva and beeswax with exudate gathered from tree buds, sap flows, or other botanical sources. It is used as a sealant for unwanted open spaces in the hive. Propolis is used for small gaps, while larger spaces are usually filled with beeswax. Its color varies depending on its botanical source, the most common being dark brown. Propolis is sticky at, and above, room temperature. At lower temperatures, it becomes hard and very brittle. Propolis also has great medicinal qualities and can be added to alchohol to make tinctures to treat various ailments.